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Lentil-Derived Bioactives for Gastrointestinal Health: Potential Complementary Interactions Among Peptides, Resistant
Xingye Wei1, Qianwen Sun2, Chengxuan Li1
1School of Agriculture, Food and Ecosystem Sciences, Faculty of Science, The University of Melbourne, Parkville, VIC 3010, Australia.
Nutrients
|May 13, 2026
Summary
Lentils offer gut health benefits through bioactive peptides, resistant starch, and polyphenols. Their complementary interactions within the food matrix require further study to confirm synergistic effects on gut health.
Area of Science:
- Nutritional Science
- Gastroenterology
- Food Science
Background:
- Lentils (Lens culinaris) are functional legumes containing bioactive peptides, resistant starch, and polyphenols.
- Existing research often isolates lentil compounds, neglecting their matrix-dependent interactions during digestion and fermentation.
- Understanding these interactions is crucial for elucidating lentil's gut health benefits.
Purpose of the Study:
- To review and synthesize evidence on lentil-derived peptides, resistant starch, and polyphenols.
- To emphasize their matrix-dependent complementary relationships, digestion transformation, and microbial co-metabolism.
- To explore their implications for intestinal barrier function and gut health.
Main Methods:
- Literature review synthesizing current evidence on lentil bioactives.
- Analysis of digestion-dependent transformations and microbial co-metabolism.
- Examination of mechanistic pathways influencing gut barrier function.
Main Results:
- Lentil components transform during digestion and fermentation into bioactive peptides, SCFAs, and phenolic metabolites.
- These transformations influence microbial activity and may improve gut barrier function via microbiota-host crosstalk.
- Evidence suggests matrix-dependent complementary actions, with phenolic fractions showing clearer pathway evidence.
Conclusions:
- Lentil bioactives exert beneficial effects on gut health through interconnected processes, including SCFA signaling and antioxidant defenses.
- Current evidence supports complementary actions, but robust human trials are needed to confirm synergy.
- Further research should focus on testing interaction effects within realistic lentil matrices.
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