[Research Advances in Obstructive Sleep Apnea and Lung Cancer Comorbidity]

Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder characterized by recurrent upper airway collapse and apnea during sleep, resulting in intermittent hypoxia, oxidative stress, and systemic inflammation, and is closely associated with multisystem dysfunction, including cardiovascular disease, cognitive impairment, and metabolic abnormalities. Lung cancer remains one of the leading causes of cancer-related mortality worldwide and represents a major threat to human health. Recent studies suggest that OSA and lung cancer share several common risk factors, including smoking, older age, and obesity, and exhibit overlapping pathophysiological mechanisms, indicating that OSA may be involved in the initiation and progression of lung cancer. However, the epidemiological evidence regarding the association between OSA and lung cancer remains inconsistent, and the underlying molecular mechanisms as well as the clinical value of potential interventions have yet to be systematically elucidated. This review therefore summarizes the epidemiological characteristics, potential pathophysiological mechanisms, and therapeutic strategies related to the coexistence of OSA and lung cancer, with the aim of providing a theoretical basis for clinical decision-making and future mechanistic studies.
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