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Published on: January 30, 2014
Natural Product Rengyolone Attenuates LPS-Induced Microglia Inflammation via Suppression of the TLR4/NF-κB Pathway
Zhao-Ting Li1,2, Qi-Chao Sun1,2, Xue-Mei Yang3
1School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, China.
Abstract:
Rengyolone, a cyclohexylethanol derivative isolated from Incarvillea mairei (Bignoniaceae), exhibited a potent anti-inflammatory effect in LPS-stimulated BV-2 cells by inhibiting the release of the inflammatory mediators nitric oxide (NO) and prostaglandin E2 (PGE2), as well as downregulating the levels of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) and elevating the level of the anti-inflammatory cytokine IL-10. Further investigation revealed that rengyolone exerts its anti-inflammatory effect in microglia by suppressing the protein expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), as well as by blocking the TLR4/NF-κB signaling pathway. These results suggest that rengyolone may be a promising lead compound for the treatment of neuroinflammation.
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