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Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
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Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

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Male Sexual Response: Erection & Ejaculation

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The Placebo Effect01:54

The Placebo Effect

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Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

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Related Experiment Video

Updated: May 14, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Unveiling Treatment Adherence Gaps in Psychogenic Versus Organic Erectile Dysfunction.

Massimiliano Raffo1,2, Christian Corsini1,2, Edoardo Pozzi1,2

  • 1Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.

Andrology
|May 13, 2026
PubMed
Summary

Men with primary organic erectile dysfunction (PO-ED) showed poorer adherence to phosphodiesterase type 5 inhibitor (PDE5i) therapy compared to those with primary psychogenic erectile dysfunction (PP-ED). This highlights the need for tailored treatment strategies for different ED etiologies.

Keywords:
erectile dysfunctionorganic erectile dysfunctionphosphodiesterase 5 inhibitorspsychogenic erectile dysfunctiontherapy discontinuation

Related Experiment Videos

Last Updated: May 14, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Area of Science:

  • Urology
  • Andrology
  • Pharmacotherapy

Background:

  • Erectile dysfunction (ED) is classified by etiology into primary organic (PO-ED) and primary psychogenic (PP-ED).
  • Phosphodiesterase type 5 inhibitors (PDE5i) are a common treatment for ED.
  • Assessing therapy adherence across different ED subtypes is crucial for optimizing patient outcomes.

Purpose of the Study:

  • To compare adherence rates to PDE5i therapy between men with PP-ED and PO-ED.
  • To identify factors influencing treatment discontinuation in ED patients.

Main Methods:

  • Retrospective analysis of 1252 men with ED treated with PDE5i.
  • Patients categorized into PO-ED (presence of risk factors) and PP-ED (absence of risk factors) groups.
  • Adherence evaluated using Kaplan-Meier analysis and Cox regression over 16 years.

Main Results:

  • PO-ED patients (83%) were older with more comorbidities than PP-ED patients (17%).
  • Overall discontinuation rate was 49%, with similar rates between groups (45% PP-ED vs. 49.8% PO-ED).
  • Adherence was significantly poorer in the PO-ED group (p < 0.001). PO-ED and sedentary lifestyle predicted discontinuation.

Conclusions:

  • Adherence to PDE5i therapy is significantly lower in men with PO-ED compared to PP-ED.
  • Identifiable organic risk factors are associated with poorer treatment adherence.
  • Tailored adherence strategies may be necessary for patients with PO-ED.