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Related Concept Videos

Resting Potential Decay01:15

Resting Potential Decay

The resting membrane potential of a neuron (-70mV) is sustained due to the selective ion permeability of the membrane. At the resting potential, the membrane is slightly permeable to ions like sodium (Na+) and chloride (Cl−) and highly permeable to potassium ions (K+). Differences in the ions' concentration inside the cell compared to the outside are maintained by membrane transport proteins like channels and pumps.
At rest, the K+ is the main ion that moves across the membrane through...
ATP Driven Pumps I: An Overview01:27

ATP Driven Pumps I: An Overview

ATP-driven pumps, also known as transport ATPases, are integral membrane proteins. They have binding sites for ATP located on the membrane's cytosolic side and the ion-conducting domain in the transmembrane region. These pumps use the free energy released from ATP hydrolysis to move the solutes across cell membranes against an electrochemical gradient.
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The Resting Membrane Potential01:21

The Resting Membrane Potential

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Potentiometry: Membrane Electrodes01:15

Potentiometry: Membrane Electrodes

Membrane electrodes, also known as p-ion electrodes, use membranes that selectively interact with free analyte ions, generating a potential difference across the membrane. The resulting membrane potential, known as the asymmetry potential, is not zero even when analyte concentrations on both sides of the membrane are equal. The membrane's response is typically not selective to a single analyte but proportional to the concentration of all ions in the sample solution capable of interacting at the...
Generation of Action Potential in Skeletal Muscles01:24

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Every cell in the body maintains a membrane potential due to an uneven distribution of positive and negative charges across its plasma membrane. The membrane potential is measured in millivolts and quantifies the difference in charge across the membrane.
Like neurons, muscle cells are also regarded as excitable due to their capacity to change in response to stimuli, primarily due to voltage-gated ion channels embedded in their plasma membranes, which get activated by alterations in the cell's...
Primary Active Transport01:47

Primary Active Transport

In contrast to passive transport, active transport involves a substance being moved through membranes in a direction against its concentration or electrochemical gradient. There are two types of active transport: primary active transport and secondary active transport. Primary active transport utilizes chemical energy from ATP to drive protein pumps that are embedded in the cell membrane. With energy from ATP, the pumps transport ions against their electrochemical gradients—a direction they...

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Contribution of the Na+/K+ Pump to Rhythmic Bursting, Explored with Modeling and Dynamic Clamp Analyses
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Published on: May 9, 2021

Efficient Dynamic Potential Stabilization via a Bioinspired Ion Pump Prevents Sensing Signals Drift.

Dandan Lei1,2, Qixiang Zhang2,3, Shulong Li1

  • 1Institute for Advanced Study, Chengdu University, Chengdu, Sichuan, China.

Advanced Materials (Deerfield Beach, Fla.)
|May 13, 2026
PubMed
Summary

This study introduces an oxygen-driven ion pump inspired by biological systems to power artificial sensors. This innovation overcomes energy depletion, enabling stable, self-powered operation for extended periods.

Keywords:
V2O5ion pumpsensorsignal drift

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Area of Science:

  • Electrochemistry
  • Materials Science
  • Bioinspired Engineering

Background:

  • Artificial ion-sensing systems require external power, leading to stability issues due to energy depletion and potential decay.
  • Existing systems lack active ion regulation mechanisms found in biological pumps, hindering sustained performance.

Purpose of the Study:

  • To develop an oxygen-driven bioinspired ion pump to overcome energy supply challenges in potentiometric sensors.
  • To emulate biological active transport for sustained electrode potential stability and enhanced ion storage.

Main Methods:

  • Exploited oxygen-sensitive O─Zn bonds in NH4+-intercalated V2O5 for Zn2+ extraction and reverse pumping.
  • Utilized theoretical simulations to elucidate the mechanism of oxygen-driven ion pumping.
  • Constructed and tested a self-powered respiration sensor in ambient air.

Main Results:

  • Achieved efficient Zn2+ extraction and reverse pumping in oxygen-rich environments, mimicking biological active transport.
  • Demonstrated sustained electrode potential stability and enhanced ion-storage capacity of V2O5.
  • The self-powered sensor operated stably for 480 hours with minimal degradation (0.2%) in ambient air, unlike oxygen-free environments (13.9%).

Conclusions:

  • An oxygen-driven bioinspired ion-pumping strategy effectively overcomes energy supply limitations in potentiometric sensors.
  • This approach offers a novel pathway for developing self-powered, stable ion-sensing systems.
  • The bioinspired pump design enhances electrode potential stability and ion-storage capacity.