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Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...

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Updated: May 14, 2026

Direct Drug Delivery to Kidney via the Renal Artery
11:18

Direct Drug Delivery to Kidney via the Renal Artery

Published on: April 17, 2021

Biodegradable Intra-arterial Devices for Focal Drug Delivery to Targeted Organs.

Manas Kinra1, Ruoyu Sheng2,3, Yiqing Chen1,2

  • 1Department of Molecular, Cell and Systems Biology, University of California at Riverside, Riverside, CA 92521, USA.

Biorxiv : the Preprint Server for Biology
|May 13, 2026
PubMed
Summary
This summary is machine-generated.

Biodegradable intra-arterial drug delivery devices made from magnesium and poly(glycerol sebacate) offer targeted treatment. These devices enhance drug efficacy in organs while reducing systemic toxicity, showing promise for various clinical applications.

Keywords:
Biocompatible endovascular implantsBiodegradable Intra-arterial drug delivery (IADD) devicesFocal drug deliveryMagnesium based implantsPoly(glycerol sebacate) (PGS)Sustained drug release

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Intraluminal Drug Delivery to the Mouse Arteriovenous Fistula Endothelium
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Intraluminal Drug Delivery to the Mouse Arteriovenous Fistula Endothelium

Published on: March 4, 2016

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Medical Devices

Background:

  • Systemic drug administration often leads to toxicity and reduced efficacy due to non-specific distribution.
  • Targeted drug delivery systems are needed to improve therapeutic outcomes and minimize side effects.

Purpose of the Study:

  • To develop and characterize biodegradable intra-arterial drug delivery (IADD) devices for focal organ treatment.
  • To evaluate the drug release kinetics, cytocompatibility, and *in vivo* efficacy of IADD devices.

Main Methods:

  • Fabrication of IADD devices using magnesium (Mg) and poly(glycerol sebacate) (PGS) with helical and linear designs.
  • Characterization using SEM, EDS, TGA, and FTIR; *in vitro* drug release studies; cell viability assays; and *in vivo* studies in rat models.

Main Results:

  • Successful fabrication and drug incorporation (dexamethasone or cisplatin) into IADD devices.
  • Sustained drug release over 30 days *in vitro* with demonstrated cytocompatibility and anti-glioma activity.
  • *In vivo* studies showed significant improvements in organ drug levels (109-fold for kidney, 68-fold for brain) compared to oral administration.

Conclusions:

  • IADD devices are safe and effective for sustained, focal drug delivery to target organs, reducing systemic exposure.
  • This technology holds potential for treating various conditions by delivering potent drugs with narrow therapeutic windows.