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Updated: May 14, 2026

Tension Gauge Tether Probes for Quantifying Growth Factor Mediated Integrin Mechanics and Adhesion
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Tension Gauge Tether Probes for Quantifying Growth Factor Mediated Integrin Mechanics and Adhesion

Published on: February 11, 2022

Direct tensile force activates Adgrl3 in a tethered agonist-dependent manner

Jesper F L Holmkvist, Luis Hamel, Younes F Barooji

    Biorxiv : the Preprint Server for Biology
    |May 13, 2026
    PubMed
    Summary

    Mechanical force directly activates adhesion G protein-coupled receptors (GPCRs). Applying tensile force to Adgrl3 using optical tweezers induced G protein recruitment, demonstrating GPCRs as cellular mechanosensors.

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