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Coexisting Hepatic and Renal Dysfunction During Pulmonary Tuberculosis Treatment: A Case Report
Irfan Malik1, Nosheen Farooq2, Maheen Sheraz3
1University of Lahore Lahore Pakistan.
Clinical Case Reports
|May 13, 2026
Summary
Tuberculosis treatment can rarely cause liver and kidney damage, indicated by positive ANCA tests suggesting an immune response. Early intervention and adjusted treatment are crucial for managing this rare side effect.
Area of Science:
- Internal Medicine
- Nephrology
- Hepatology
- Immunology
Background:
- Anti-tuberculosis therapy is essential for treating tuberculosis.
- Concurrent liver and kidney injury is a rare but serious adverse effect of anti-tuberculosis drugs.
- Anti-neutrophil cytoplasmic antibody (ANCA) positivity may indicate immune system involvement in drug-induced organ damage.
Purpose of the Study:
- To report a rare case of concurrent liver and kidney injury during anti-tuberculosis therapy.
- To emphasize the diagnostic significance of ANCA positivity in such cases.
- To highlight the importance of prompt recognition and management of this adverse event.
Main Methods:
- Case report detailing clinical presentation, laboratory findings, and treatment course.
- Review of relevant literature on drug-induced liver and kidney injury.
- Discussion of the role of ANCA in autoimmune phenomena.
Main Results:
- The patient developed concurrent liver and kidney injury during anti-tuberculosis treatment.
- ANCA positivity was observed, suggesting an immune-mediated mechanism.
- Treatment modification and supportive care led to recovery.
Conclusions:
- Concurrent liver and kidney injury is a rare but critical complication of anti-tuberculosis therapy.
- ANCA positivity can serve as a marker for immune involvement.
- Multidisciplinary management, including early recognition and treatment adjustment, is vital for favorable outcomes in tuberculosis patients experiencing organ injury.
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