Formulation Progress, Challenges, and Perspectives of Anti-Inflammatory Natural Products
Hongran Fang1, Ailing Wu2, Muxin Zhao1
1School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, People's Republic of China.
Drug Design, Development and Therapy
|May 13, 2026
Summary
Natural anti-inflammatory drugs offer safe, multi-target therapeutic potential. Challenges include toxic excipients and insufficient commercial translation, requiring further research for broader application.
Area of Science:
- Pharmacology
- Natural Product Chemistry
- Drug Development
Background:
- Inflammation is a critical biological response to harmful stimuli.
- Natural anti-inflammatory drugs present promising alternatives due to safety and efficacy.
- Compounds like EGCG and Luteolin exhibit potent anti-inflammatory mechanisms.
Purpose of the Study:
- To review the potential of natural anti-inflammatory drugs.
- To discuss advancements in formulation and emerging technologies.
- To highlight challenges in biosafety and commercialization.
Main Methods:
- Literature review of natural anti-inflammatory agents.
- Analysis of formulation technologies including 3D printing and AI.
- Evaluation of safety profiles and commercialization barriers.
Main Results:
- Natural drugs like EGCG and Luteolin demonstrate significant anti-inflammatory actions.
- Innovative formulation strategies are enhancing drug delivery.
- Toxic excipients and commercialization hurdles remain key concerns.
Conclusions:
- Natural anti-inflammatory drugs hold substantial therapeutic promise.
- Addressing biosafety and production challenges is crucial for clinical translation.
- Further research is needed to fully realize the potential of these agents.
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