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Patient With MGRS/PGNMID Without Detection of a Peripheral Clone: Case Report and Literature Review
Agatha Larrazábal1,2, Ana Ávila-Rodriguez3, Matías Sánchez3
1Department of Hematology at Fundación Arturo López Pérez, Santiago de Chile, Chile.
Abstract:
Monoclonal gammopathy of renal significance (MGRS) is a clonal cell proliferative disorder, characterized by the production of monoclonal immunoglobulins in patients that do not meet hematological criteria for a specific malignancy. It can be present in B cell and plasma cell clonal proliferative diseases and accounts for 10% of monoclonal gammopathy of undetermined significance (MGUS) cases. We present a case of a patient presenting with acute kidney injury, hematuria, and nephrotic syndrome, who after renal biopsy was diagnosed with a proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMIDs), a subtype of MGRS, and treated with chemoimmunotherapy (daratumumab, cyclophosphamide, bortezomib, and dexamethasone), with complete renal function recovery.