Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chromatin landscape and epigenetic heterogeneity of acute myeloid leukaemia.

Nature·2026
Same author

Automated Tractography Settings for Assessing the Corticoreticular Pathway in Patients With Stroke: A Clinical Application.

Cureus·2026
Same author

Absence of Pretransplant Peripheral Blasts Is a Favorable Factor in Allogeneic Stem Cell Transplantation for Advanced Acute Lymphoblastic Leukemia.

Transplantation and cellular therapy·2026
Same author

Early Transplantation After Pretransplant Reduction of <i>TP53</i>-Altered Clones and Prolonged Dose-Adjusted Azacitidine Maintenance: A Three-Case Series.

EJHaem·2026
Same author

Comparative outcomes of umbilical cord blood transplantation versus haploidentical transplantation according to post-transplant cyclophosphamide use in adolescent and young adult patients.

Bone marrow transplantation·2026
Same author

Association between total corticosteroid dose and reduced fast-twitch rectus femoris muscle fibers after hematopoietic stem cell transplantation.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2026

Related Experiment Video

Updated: May 14, 2026

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
08:02

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

Relationship between Corticosteroid Dose and Physical Performance after HSCT: A Prospective Cohort Study.

Nobuyoshi Nishikado1, Tatsushi Wakasugi2, Katsuji Kaida3

  • 1Department of Rehabilitation, Hyogo Medical University Hospital, Nishinomiya, Japan.

Progress in Rehabilitation Medicine
|May 13, 2026
PubMed
Summary

High corticosteroid doses predict difficulty standing after hematopoietic stem cell transplantation (HSCT). Careful evaluation of standing ability is crucial for patients receiving significant steroid treatment.

Keywords:
glucocorticoid-induced muscle atrophyhematopoietic stem cell transplantationrehabilitationshort physical performance batterystanding ability

More Related Videos

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
11:06

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

Related Experiment Videos

Last Updated: May 14, 2026

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
08:02

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
11:06

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

Area of Science:

  • Hematology
  • Transplantation Medicine
  • Rehabilitation Science

Background:

  • Hematopoietic stem cell transplantation (HSCT) can lead to significant physical deconditioning.
  • Diminished ability to perform basic functional movements, such as standing up, is a common post-transplant complication.

Purpose of the Study:

  • To prospectively identify factors influencing the reduced ability to stand up after HSCT.
  • To investigate the association between corticosteroid dose and post-HSCT physical performance decline.

Main Methods:

  • Fifty patients undergoing HSCT were prospectively studied.
  • Physical performance was assessed pre- and post-transplant using the Short Physical Performance Battery (SPPB).
  • Logistic regression analysis identified factors associated with a decline in the SPPB chair rise score.

Main Results:

  • A notable functional decline in standing ability was observed post-HSCT.
  • The total corticosteroid dose emerged as an independent predictor of this physical performance decline (OR, 1.03; 95% CI, 1.00-1.05).

Conclusions:

  • Total corticosteroid dose is a significant predictor of post-HSCT physical performance decline.
  • Patients anticipated to receive high-dose corticosteroids require cautious evaluation of their ability to perform standing movements.