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Relationship between Corticosteroid Dose and Physical Performance after HSCT: A Prospective Cohort Study
Nobuyoshi Nishikado1, Tatsushi Wakasugi2, Katsuji Kaida3
1Department of Rehabilitation, Hyogo Medical University Hospital, Nishinomiya, Japan.
Objectives:
This study aimed to prospectively investigate the factors affecting the diminished ability of patients to stand up following hematopoietic stem cell transplantation (HSCT).
Methods:
Fifty patients were enrolled in the study. Pre- and post-HSCT physical performance was assessed using the Short Physical Performance Battery (SPPB). Post-HSCT physical performance decline was defined as a decrease of at least 1 point in the SPPB chair rise score at hospital discharge compared with the pre-HSCT score. Factors associated with this decline were analyzed using multiple logistic regression.
Results:
A functional decline in the ability to stand up post-HSCT was noted. The total corticosteroid dose (odds ratio, 1.03, 95% confidence interval 1.00-1.05) showed an independent association with physical performance decline post-HSCT.
Conclusions:
The total corticosteroid dose is a valuable predictor of physical performance decline post-HSCT. Therefore, standing up movements should be evaluated cautiously in patients who are expected to receive high corticosteroid doses for the treatment of acute graft-versus-host disease or HSCT regimens.
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