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Relationship between Corticosteroid Dose and Physical Performance after HSCT: A Prospective Cohort Study
Nobuyoshi Nishikado1, Tatsushi Wakasugi2, Katsuji Kaida3
1Department of Rehabilitation, Hyogo Medical University Hospital, Nishinomiya, Japan.
Progress in Rehabilitation Medicine
|May 13, 2026
Summary
High corticosteroid doses predict difficulty standing after hematopoietic stem cell transplantation (HSCT). Careful evaluation of standing ability is crucial for patients receiving significant steroid treatment.
Area of Science:
- Hematology
- Transplantation Medicine
- Rehabilitation Science
Background:
- Hematopoietic stem cell transplantation (HSCT) can lead to significant physical deconditioning.
- Diminished ability to perform basic functional movements, such as standing up, is a common post-transplant complication.
Purpose of the Study:
- To prospectively identify factors influencing the reduced ability to stand up after HSCT.
- To investigate the association between corticosteroid dose and post-HSCT physical performance decline.
Main Methods:
- Fifty patients undergoing HSCT were prospectively studied.
- Physical performance was assessed pre- and post-transplant using the Short Physical Performance Battery (SPPB).
- Logistic regression analysis identified factors associated with a decline in the SPPB chair rise score.
Main Results:
- A notable functional decline in standing ability was observed post-HSCT.
- The total corticosteroid dose emerged as an independent predictor of this physical performance decline (OR, 1.03; 95% CI, 1.00-1.05).
Conclusions:
- Total corticosteroid dose is a significant predictor of post-HSCT physical performance decline.
- Patients anticipated to receive high-dose corticosteroids require cautious evaluation of their ability to perform standing movements.
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