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The effects of revascularization of lower extremity arterial disease on cardiac diastolic functions

İsmail Balaban1, Kenan Toprak2, Seda Tanyeri1

  • 1Department of Cardiology, University of Health Sciences Türkiye, Hamidiye Faculty of Medicine, Koşuyolu High Specialization Training and Research Hospital, İstanbul, Türkiye.

Turk Gogus Kalp Damar Cerrahisi Dergisi
|May 13, 2026
PubMed

Insights

Endovascular revascularization improved diastolic function in patients with lower extremity arterial disease (LEAD). Echocardiographic indices showed early positive changes, but long-term clinical significance requires further study.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Echocardiography

Background:

  • Lower extremity arterial disease (LEAD) is linked to arterial stiffness and left ventricular diastolic dysfunction (LVDD).
  • Endovascular revascularization improves limb perfusion but its impact on LVDD is not well understood.
  • Assessing early echocardiographic changes in LVDD post-revascularization is crucial.

Purpose of the Study:

  • To evaluate early echocardiographic changes in LVDD indices after successful endovascular revascularization in LEAD patients.
  • To determine the immediate effects of revascularization on diastolic function parameters.
  • To investigate the relationship between LEAD location and changes in diastolic function.

Main Methods:

  • Prospective single-center study of 74 LEAD patients undergoing endovascular revascularization.
  • Transthoracic echocardiography performed pre- and post-intervention (within 120 hours).
  • Measured diastolic indices: e' velocity, E/e' ratio, IVRT, and IVRT/TE-e', analyzed using linear mixed-effects models.

Main Results:

  • Significant improvements in diastolic function observed: increased e' velocity (p=0.036), decreased E/e' ratio (p<0.001).
  • Isovolumetric relaxation time (IVRT) and IVRT/TE-e' ratio also significantly decreased (p=0.029, p=0.018).
  • Aortoiliac disease correlated with greater IVRT/TE-e' ratio reduction (p=0.021); no changes in systolic function or hemodynamics.

Conclusions:

  • Successful endovascular revascularization in LEAD patients leads to early improvements in LVDD echocardiographic indices.
  • These findings suggest a potential benefit of revascularization on cardiac function.
  • Further research is needed to establish the long-term clinical significance of these diastolic improvements.
Abstract

Keywords:
Lower extremity arterial diseasediastolic indicesechocardiographyendovascular revascularizationmyocardial relaxation

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