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Defibrotide-Responsive Cutaneous Endothelial Injury Following Allogeneic Hematopoietic Stem Cell Transplant: A Case

Burcu Aslan Candir1, Bahar Ulu Uncu, Kubra Citlak

  • 1>From the Department of Hematology and Bone Marrow Transplantation Center,Ankara Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital,Ankara, Türkiye.

Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation
|May 13, 2026
PubMed
Summary

Defibrotide effectively treated skin lesions and liver complications in a patient after stem cell transplant, indicating its potential for systemic endothelial protection beyond the liver.

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...