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Updated: May 14, 2026

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
Published on: October 25, 2019
CAROTID BODY CHEMORECEPTORS: FROM MOUNTAIN TO SPACE
David C Andrade1, Camila Salazar-Ardiles2, Bayron García-Ordenes1,3
1Exercise Applied Physiology Laboratory, High Altitude Physiology and Medicine Research Center, Biomedical Department, Faculty of Health Sciences, University of Antofagasta, Antofagasta, Chile.
None:
Human acclimatization to both high-altitude and microgravity is crucial for terrestrial and space exploration. Although these extreme environments elicit several similar physiological responses, including autonomic imbalance, metabolic stress, and reduced exercise capacity, the underlying central mechanisms remain unclear. However, these effects appear to be linked to chemoreflex control. This review summarizes current evidence and proposed potential similarities and bioconvergent mechanisms underlying human responses to both terrestrial and extraterrestrial environments.
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