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Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...

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Related Experiment Video

Updated: May 14, 2026

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells
12:46

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells

Published on: August 17, 2022

Lymphatic Matters in Heart Disease: Systemic and Cardiac Perspectives.

Benjamin Kelly1, Tobias Wang2, Vibeke E Hjortdal1,3

  • 1Department of Thoracic Surgery, The Heart Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.

Physiology (Bethesda, Md.)
|May 13, 2026
PubMed
Summary

The lymphatic system is crucial for cardiovascular health, influencing fluid balance and lipid transport. Dysfunctional lymphatic system contributes to heart disease development and progression.

Keywords:
Comparative cardiologyEdemaHeart failureLymphatic heartsLymphatic vessel

Related Experiment Videos

Last Updated: May 14, 2026

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells
12:46

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells

Published on: August 17, 2022

Area of Science:

  • Cardiovascular Physiology
  • Lymphatic System Biology

Background:

  • The lymphatic system is vital for fluid homeostasis, immune cell transport, and lipid absorption.
  • Lymphatic performance is intrinsically linked to cardiovascular health.
  • Impaired lymphatic function can precipitate or exacerbate cardiovascular diseases.

Purpose of the Study:

  • To review the intricate relationship between the lymphatic and cardiovascular systems.
  • To emphasize the role of systemic lymphatic function in cardiovascular pathology.
  • To explore emerging diagnostic and therapeutic strategies targeting the lymphatic system for cardiovascular diseases.

Main Methods:

  • Review of existing clinical and experimental evidence.
  • Examination of lymphatic vasculature structure and physiology.
  • Discussion of comparative and translational lymphatic strategies.

Main Results:

  • Lymphatic dysfunction contributes to edema, inflammation, and organ impairment in conditions like heart failure and atherosclerosis.
  • Altered lymph formation, transport, and venous return are implicated in cardiovascular disease progression.
  • Diverse lymphatic strategies across vertebrates offer insights into regulation and research.

Conclusions:

  • The lymphatic system is a critical determinant of cardiovascular physiology and disease.
  • Lymphatic function must be considered alongside the blood circulation in research and clinical practice.
  • Targeting lymphatic system offers potential for novel cardiovascular disease treatments.