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Updated: May 14, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

Pattern and Predictors of Bronchopulmonary Dysplasia in Preterm Infants in New South Wales, Australia: A

Syeda Mah-E-Muneer1, Jahidur Rahman Khan1, Mei Chan1

  • 1School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.

Acta Paediatrica (Oslo, Norway : 1992)
|May 13, 2026
PubMed

Insights

Bronchopulmonary dysplasia (BPD) incidence is rising in preterm infants, especially extremely preterm (EPT) survivors. However, reduced overall preterm mortality is offsetting this trend, necessitating future healthcare planning for increased BPD survivors.

Area of Science:

  • Neonatalogy
  • Pediatric Pulmonology
  • Public Health

Background:

  • Bronchopulmonary dysplasia (BPD) is a significant complication in preterm infants.
  • Understanding population-level trends in BPD and mortality is crucial for healthcare planning.

Purpose of the Study:

  • To analyze the population patterns of BPD, mortality, and composite BPD/death outcomes in Australian preterm infants.
  • To identify risk factors associated with these outcomes across different gestational ages.

Main Methods:

  • Retrospective population study utilizing linked statewide health administrative data (2005-2015).
  • Incidence of BPD, death, and composite outcomes stratified by extremely preterm (EPT), very preterm (VPT), and moderate-to-late preterm (MPT) infants.
  • Generalized estimating equation logistic regression models were used to analyze risk factors.

Main Results:

  • BPD incidence was highest in EPT infants (324.6/1000), followed by VPT (89.7/1000) and MPT (1.5/1000).
  • Annual BPD incidence increased from 2005 to 2015 (p < 0.001), while the composite outcome decreased due to reduced mortality (p < 0.001).
  • Key risk factors for BPD, death, and composite outcomes included being born EPT, assisted vaginal/breech delivery, small-for-gestational-age, male sex, and low 5-min APGAR score.

Conclusions:

  • Rising BPD incidence, particularly among EPT survivors, is currently offset by declining preterm mortality.
  • Healthcare systems must prepare for an increasing number of BPD survivors.
Abstract

Keywords:
New South Walesbronchopulmonary dysplasiapatternpredictorspreterm

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