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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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Rapid Onset of Iron Overload Cardiomyopathy in Cirrhosis

Cyrus M Nouraee1, William H Swain2, David M Harmon2

  • 1Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.

JACC. Case Reports
|May 13, 2026
PubMed

Insights

Iron overload cardiomyopathy (IOC) can occur in cirrhosis patients without hereditary hemochromatosis. Early diagnosis and iron chelation are crucial for managing this heart failure complication in liver disease.

Area of Science:

  • Cardiology
  • Hepatology
  • Medical Imaging

Background:

  • Iron overload cardiomyopathy (IOC) is a rare heart failure cause, typically linked to hereditary or transfusion-related hemochromatosis.
  • The occurrence and progression of IOC in cirrhosis patients are not well-documented, despite iron accumulation in cirrhosis.

Keywords:
T2∗ mappingcardiac magnetic resonance imagingcirrhosishepatic iron overloadiron overload cardiomyopathy (IOC)myocardial iron deposition

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