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Updated: May 14, 2026

Calibration Procedures for Orthogonal Superposition Rheology
Published on: November 18, 2020
Recalibrating Dual Checkpoint Blockade? Lessons from Volrustomig
Jong Chul Park1,2, Justin F Gainor1,2
1Division of Hematology/Oncology, Mass General Brigham Cancer Institute, Boston, Massachusetts.
None:
Dual programmed cell death protein 1 (PD-1)/cytotoxic T lymphocyte-associated protein 4 (CTLA-4) inhibition improves outcomes in several cancers but remains limited by toxicity. A recent article reports the first-in-human study of volrustomig, a novel PD-1/CTLA-4 bispecific antibody, demonstrating durable responses, but dose-dependent immune-related adverse events were also observed. This commentary examines whether the bispecific format meaningfully improves the therapeutic index and considers priorities for the next phase of development. See related article by Tran et al., p. 2850.
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