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Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
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Autonomic Nervous System: Overview01:26

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Organization of the Nervous System01:13

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Nervous System01:21

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Extending...
Peripheral Nervous System: Ganglia and Nerves01:24

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Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE
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Published on: April 15, 2014

APC in the nervous system.

Takao Senda1, Nami O Yamada2, Takanori Onouchi3

  • 1Department of Food and Nutrition Management, Faculty of Human Health, Sonoda University, 7-29-1 Minamitsukaguchi-Cho Amagasaki, Hyogo, 661-8520, Japan. tsenda@sonoda-u.ac.jp.

Medical Molecular Morphology
|May 13, 2026
PubMed
Summary
This summary is machine-generated.

The adenomatous polyposis coli (APC) gene, crucial for brain development and function, plays a role in neural circuit formation. Aberrant APC function may link to neurological disorders like autism and schizophrenia.

Keywords:
Adenomatous polyposis coli (APC)Autism spectrum disorderAxon elongationBrain developmentCognitive impairmentMicrotubulesNeuron immigrationPSD-95SchizophreniaSynaptic transmission

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Area of Science:

  • Neuroscience
  • Genetics
  • Molecular Biology

Background:

  • The adenomatous polyposis coli (APC) gene, initially identified as a tumor suppressor, is highly expressed in the nervous system.
  • APC plays critical roles in brain development, morphogenesis, synaptic transmission, and intracellular transport in the postnatal brain.

Purpose of the Study:

  • To investigate the multifaceted roles of the APC gene and its protein product in the central nervous system.
  • To explore the potential involvement of APC in neurological and psychiatric disorders.

Main Methods:

  • Review of existing literature on APC gene expression and function in the nervous system.
  • Analysis of data from disease model animals and human patients with familial adenomatous polyposis (FAP).

Main Results:

  • APC is integral to glial cell differentiation and neural circuit formation via glial cell functions.
  • Evidence suggests a potential link between APC dysfunction and conditions such as autism, cognitive impairment, and schizophrenia.

Conclusions:

  • The APC gene is a key player in brain development and neural circuit organization.
  • Dysregulation of APC may contribute to the pathophysiology of various neurological and psychiatric disorders.