Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 14, 2026

Live Imaging of Drug Responses in the Tumor Microenvironment in Mouse Models of Breast Cancer
08:26

Live Imaging of Drug Responses in the Tumor Microenvironment in Mouse Models of Breast Cancer

Published on: March 24, 2013

Mitochondrial Imaging Detects Early Cardiac Changes Following Cancer Immunotherapy.

Hee-Don Chae1, Uttam Shrestha2, Millie Das3

  • 1CellSight Technologies (United States) San Francisco United States.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|May 13, 2026
PubMed

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Selective targeting of RSK signaling with PMD-026 suppresses FLT3-activated acute myeloid leukemia while sparing normal hematopoiesis.

Leukemia·2026
Same author

Pair production tomography enables imaging of MeV-scale gamma-emitting theranostic radionuclides.

Research square·2026
Same author

Phase I trial of CJRB-101 plus pembrolizumab in patients with metastatic non-small cell lung cancer, head and neck squamous cell carcinoma and melanoma.

Journal for immunotherapy of cancer·2026
Same author

CD39<sup>+</sup>CD49a<sup>+</sup>CD103<sup>+</sup> cytotoxic tissue-resident natural killer cells infiltrate and control solid epithelial tumor growth in mice.

Science translational medicine·2026
Same author

Detecting Bacteria in Their Mammalian Hosts Using Metabolism-Targeted [<sup>13</sup>C]CO<sub>2</sub> Breath Testing.

ACS central science·2026
Same author

Microbiome modulation in cancer immunotherapy.

Nature medicine·2026
Summary

[¹⁸F]F-AraG PET imaging can detect early cardiac changes from cancer therapies. This novel PET tracer shows potential for monitoring cardiotoxicity and immune activity during treatment.

Area of Science:

  • Nuclear medicine and molecular imaging.
  • Cardiology and cardiovascular research.
  • Oncology and cancer therapeutics.

Background:

  • Cancer therapies improve survival but risk cardiotoxicity, often detected late.
  • Current biomarkers for cardiotoxicity have limitations in early detection.
  • [¹⁸F]F-AraG PET targets mitochondrial biogenesis, relevant to cardiomyocytes and immune cells.

Purpose of the Study:

  • To evaluate [¹⁸F]F-AraG PET as an early imaging biomarker for cardiac effects.
  • To assess cardiac involvement and immune activity concurrently during cancer therapy.
  • To investigate [¹⁸F]F-AraG PET's utility across different cancer treatment modalities.

Main Methods:

  • [¹⁸F]F-AraG PET imaging in 26 healthy subjects for baseline myocardial uptake.

More Related Videos

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
09:34

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Published on: February 17, 2022

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

Related Experiment Videos

Last Updated: May 14, 2026

Live Imaging of Drug Responses in the Tumor Microenvironment in Mouse Models of Breast Cancer
08:26

Live Imaging of Drug Responses in the Tumor Microenvironment in Mouse Models of Breast Cancer

Published on: March 24, 2013

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
09:34

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Published on: February 17, 2022

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

  • Imaging 17 cancer patients (melanoma, NSCLC) before and after immunotherapy.
  • Quantification of myocardial uptake (SUVmax, SUVmean, SUVtotal) in ventricles and analysis of LV regional uptake.
  • Correlation of uptake with ECG data, mitochondrial content, and PGC-1α expression.

    • Main Results:

    • Consistent, uniform baseline myocardial [¹⁸F]F-AraG uptake observed in healthy subjects.
    • Conventional therapy increased global myocardial uptake; immunotherapy induced heterogeneous/focal uptake.
    • Altered myocardial uptake patterns correlated with ECG abnormalities.

    Conclusions:

    • [¹⁸F]F-AraG PET effectively detects therapy-associated myocardial uptake changes.
    • Findings support [¹⁸F]F-AraG PET's potential as a noninvasive early imaging biomarker for cardiotoxicity.
    • This PET tracer may aid in evaluating cardiac effects in cancer patients undergoing treatment.