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Updated: May 14, 2026

Ultra-Fast Amplicon-Based Next-Generation Sequencing in Non-Squamous Non-Small Cell Lung Cancer
Published on: September 8, 2023
HER2-Mutant Non-Small Cell Lung Cancer Podcast: Finding Patients
Vivek Subbiah1, Martin Dietrich2
1Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA. viveksubbiah@outlook.com.
Abstract:
Episode 2 in our podcast series focuses on the critical challenge of identifying patients with HER2-mutant non-small cell lung cancer (NSCLC). We discuss why timely and comprehensive testing for HER2 mutations is vital for optimizing patient outcomes and how next-generation sequencing and molecular profiling are integrated into clinical practice. This episode covers the practical aspects and evolving standards of HER2 mutation testing, including the use of tumor and liquid biopsies, and addresses real-world barriers such as cost, access, and awareness. We also explore potential solutions, such as reflex testing and collaboration with molecular pathologists, to overcome current diagnostic challenges. This episode emphasizes the importance of accurate and early molecular diagnosis in ensuring patients receive the most effective, personalized therapies as the treatment landscape for HER2-mutant NSCLC continues to advance.
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