Recurrence of monozygotic twinning after single-embryo transfer with preimplantation genetic testing: a case report
Anne E Kim1, Zev Rosenwaks2, Isaac Kligman2
1The Ronald O Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, USA. ank4039@med.cornell.edu.
Purpose:
To report a case of two monozygotic twin pregnancies after a single frozen blastocyst transfer of embryos that underwent preimplantation genetic testing.
Methods:
A 38-year-old woman pursued in vitro fertilization with preimplantation genetic testing for Gaucher's disease.
Results:
The patient underwent a natural frozen embryo transfer of a single unaffected, euploid blastocyst, which resulted in a nonviable monozygotic monochorionic-diamniotic twin pregnancy. From the same oocyte cohort, she underwent another natural frozen embryo transfer of a single unaffected, euploid blastocyst, again resulting in a nonviable monozygotic monochorionic-diamniotic twin pregnancy. Cytogenetic evaluation of the products of conception from both pregnancies was concordant with the preimplantation genetic testing results of both embryos.
Conclusion:
Recurrence of monozygotic twinning after single-embryo transfer is exceedingly rare. Further clarification is needed regarding the risk factors leading to monozygosity in assisted reproductive technology.
