Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Other Unique Bacteria01:18

Other Unique Bacteria

Magnetic bacteria exhibit a directed movement called magnetotaxis, driven by structures called magnetosomes. These magnetosomes consist of chains of magnetic particles made of either magnetite (Fe₃O₄) or greigite (Fe₃S₄) and are organized in a linear conformation by a protein scaffold within invaginations of the cell membrane. The bacteria align along the north–south magnetic field lines, much like a compass needle. They are typically microaerophilic or anaerobic and are commonly found near the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of liver T1 estimates generated by breath-hold 3D FSPGR and free-breathing 3D radial stack-of-stars FSPGR variable flip angle T1 mapping sequences.

European journal of radiology open·2026
Same author

Impact of ambient fine particulate matter (PM<sub>2.5</sub>) pollution on disease burden in BRICS from 1990 to 2023: evidence from the Global Burden of Disease Study 2023.

BMJ global health·2026
Same author

A Wireless 3D Magneto-Mechanical Stimulation Platform Drives In Situ Chondrogenic Commitment of Endogenous MSCs.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

HACC-TNF-α-VLP Nanoparticles Facilitate HSP90-Dependent Antigen Cross-Presentation to Enhance CD8⁺ T Cell and Mucosal Immunity Against Foot-and-Mouth Disease.

International journal of nanomedicine·2026
Same author

Spider-Leg-Inspired Structural Design and Bézier Foot Trajectory Planning for Stable Walking of a Hexapod Robot.

Biomimetics (Basel, Switzerland)·2026
Same author

Magneto-Actuated Antioxidative Lignin@Fe<sub>3</sub>O<sub>4</sub> Nanoclusters to Decorate a Polyelectrolyte Scaffold for Macrophage Manipulation <i>via</i> Mechano-Chemo Coordination.

ACS applied bio materials·2026

Related Experiment Video

Updated: May 15, 2026

Fabrication of Magnetic Platforms for Micron-Scale Organization of Interconnected Neurons
09:54

Fabrication of Magnetic Platforms for Micron-Scale Organization of Interconnected Neurons

Published on: July 14, 2021

Magnetic medical microrobots with memory-capable genetic circuits.

Haotian Chen1, Yujun Chen1,2, Yingying Wang1

  • 1State Key Laboratory of Autonomous Intelligent Unmanned Systems, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Collaborative Innovation Center for Brain Science, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434 China.

Science Advances
|May 13, 2026
PubMed
Summary

Scientists engineered magnetic probiotic microrobots with genetic memory for autonomous cancer treatment. These microrobots soften tumors and enhance drug delivery for improved therapeutic outcomes.

More Related Videos

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Related Experiment Videos

Last Updated: May 15, 2026

Fabrication of Magnetic Platforms for Micron-Scale Organization of Interconnected Neurons
09:54

Fabrication of Magnetic Platforms for Micron-Scale Organization of Interconnected Neurons

Published on: July 14, 2021

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Area of Science:

  • Biomedical Engineering
  • Synthetic Biology
  • Nanotechnology

Background:

  • Microrobots offer potential for minimally invasive therapy but lack onboard memory, requiring external control.
  • Limited onboard memory in microrobots restricts autonomous functions in targeted therapies.

Purpose of the Study:

  • To develop magnetic probiotic microrobots with integrated genetic memory for autonomous antitumor treatment.
  • To enable microrobots to perform sustained therapeutic actions without continuous external guidance.

Main Methods:

  • Integration of a memory-capable genetic circuit (Bxb1-ssrA-attB-P7-attP) into magnetic microrobots.
  • Utilizing a one-time magnetic hyperthermia trigger to activate the genetic memory and therapeutic state.
  • Employing magnetically controlled wave-like locomotion for enhanced tumor penetration.

Main Results:

  • Genetic memory remained active for at least 12 days, enabling sustained fibrin degradation and tumor softening.
  • Achieved a 6.70-fold reduction in tumor matrix stiffness compared to memory-absent microrobots.
  • Significantly boosted in vivo anticancer efficacy from 21.86% to 87.52%.

Conclusions:

  • The developed microrobots demonstrate autonomous antitumor treatment capabilities through genetic memory.
  • The system establishes a generalizable framework for memory-encoded medical microrobots beyond oncology.
  • This innovation paves the way for advanced, autonomous microrobotic therapies.