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CROI 2026: HIV Comorbidities

Sudipa Sarkar1, Todd T Brown1

  • 1Johns Hopkins University, Baltimore, MD, USA.

Topics in Antiviral Medicine
|May 13, 2026
PubMed

Insights

Aging HIV patients face numerous health challenges, including cardiovascular disease, fatty liver disease, and bone issues. Research at CROI 2026 highlights exercise benefits and treatment strategies for these conditions.

Area of Science:

  • Internal Medicine
  • Infectious Diseases
  • Gerontology

Background:

  • Aging-related comorbid conditions significantly impact the health, quality of life, and survival of people with HIV (PWH).
  • The 2026 Conference on Retroviruses and Opportunistic Infections (CROI) addressed various comorbid diseases in PWH.

Purpose of the Study:

  • To review key abstracts from CROI 2026 concerning aging-related comorbidities in PWH.
  • To highlight studies with the most significant clinical impact on PWH health.

Main Methods:

  • Review of abstracts presented at CROI 2026.
  • Focus on cardiovascular diseases, hypertension, metabolic dysfunction-associated fatty liver disease, antiretroviral-related weight gain, osteoporosis, and frailty in PWH.
  • Inclusion of studies from diverse geographical settings, including lower- and middle-income countries.

Main Results:

  • Cardiovascular diseases and hypertension were key topics, with analyses from the REPRIEVE trial and global studies.
  • Metabolic dysfunction-associated fatty liver disease and weight gain associated with antiretroviral therapy were prominent.
  • High prevalence of osteoporosis and frailty in PWH in sub-Saharan Africa was documented, alongside studies on exercise and physical activity benefits.

Conclusions:

  • CROI 2026 showcased critical research on managing aging-related comorbidities in PWH.
  • Clinical management strategies for cardiovascular, metabolic, and bone health in aging PWH are evolving.
  • Further research and interventions are needed to address the complex health needs of aging PWH globally.

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