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PHIP sequences and dipolar fields I - single spin control.

Martin C Korzeczek1, Ilai Schwartz2, Martin B Plenio1

  • 1Institut für Theoretische Physik & IQST, Albert-Einstein Allee 11, Universität Ulm, D-89081 Ulm, Germany.

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|May 13, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces new control sequences for parahydrogen induced polarization (PHIP) to overcome signal loss caused by magnetic field variations and sample magnetization effects in NMR.

Keywords:
Dipolar fieldHyperpolarisationPHIP

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Area of Science:

  • Nuclear Magnetic Resonance (NMR) Spectroscopy
  • Quantum Control

Background:

  • Parahydrogen induced polarization (PHIP) enhances NMR signals by transferring spin order.
  • B0/B1 field inhomogeneities and sample dipolar fields reduce PHIP efficiency in practical settings.

Purpose of the Study:

  • To develop theoretical and practical methods to counteract detrimental effects in PHIP.
  • To design and analyze control sequences for robust hyperpolarization.

Main Methods:

  • Utilized average Hamiltonian theory and numerical simulations.
  • Developed and characterized pulsed and continuous-wave (CW) control sequences.
  • Investigated dipolar-field adjusted and suppressing protocols.

Main Results:

  • Identified sequences that mitigate B0/B1 inhomogeneities and dipolar field effects.
  • Discovered conditions where dipolar interactions can unexpectedly stabilize polarization transfer.
  • Demonstrated practical guidance for designing PHIP sequences under experimental constraints.

Conclusions:

  • The developed methods enable robust hyperpolarization in concentrated liquid-state NMR.
  • Offers practical strategies for optimizing PHIP experiments in challenging conditions.