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Exploiting selected Mur enzyme characteristics for antibacterial drug design

Gizachew Muluneh Amera1, Giulia Canarutto2, Monika Jain3

  • 1Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149 Trieste, Italy; The Division of Bioinformatics and Database Management, Institute of Biotechnology, Bahir Dar University, Bahir Dar, Ethiopia; School of Bioscience and Technology, Wollo University, Dessie, Ethiopia.

Journal of Microbiological Methods
|May 13, 2026
PubMed
Summary

This review details bacterial Mur enzymes, crucial for peptidoglycan biosynthesis and antibiotic resistance. Understanding these enzymes and their inhibitors aids in developing new treatments for multidrug-resistant (MDR) and extensively drug-resistant (XDR) bacterial infections.

Keywords:
3D structuresDynamics behavior, known inhibitorsFunctional propertiesMur enzymesPeptidoglycan pathways

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