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Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
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Local immunotherapy for the treatment of cancer: scientific advances and clinical potential

Howard L Kaufman1, Tanja D de Gruijl2

  • 1Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA HLKaufman@mgh.harvard.edu.

Journal for Immunotherapy of Cancer
|May 13, 2026
PubMed

Local immunotherapy has the potential to deliver high doses of immune-potentiating agents with limited systemic toxicity. However, clinical development and implementation have been hindered by numerous challenges. Journal for ImmunoTherapy of Cancer will be addressing the potential promise of local immunotherapy and providing guidance on how to overcome current challenges in local drug development through a series of special reports over the next year.

Keywords:
Immune modulatoryImmunotherapyIntralesional

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