Related Experiment Video
Updated: May 15, 2026

Mouse In Vivo Placental Targeted CRISPR Manipulation
Published on: April 14, 2023
[The programming effects of the placenta on offspring neurobehavioral development]
1Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230032, China MOE Key Laboratory of Population Health Across Life Cycle/Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Course, Hefei 230032.
Abstract:
Neurobehavioral development in offspring is shaped by multiple interacting determinants. As a critical organ during gestation and fetal development, the placenta exerts programming effects on offspring neurobehavioral outcomes through diverse mechanisms. This article systematically examines the programming role of placental factors from the following perspectives: placental barrier function, placental pathological alterations, neuroendocrine pathways, epigenetic regulation, and immunomodulatory mechanisms. In addition, it explores potential mechanisms underlying sex-specific influences on offspring neurodevelopment, providing a comprehensive perspective for understanding placenta-derived neurodevelopmental abnoramlities.

