Related Experiment Video

Updated: May 15, 2026

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

Nanotechnology-enhanced Natural Products for Cancer Chemoprevention: Molecular Mechanisms and Clinical Translation

Rajat Nath1, Sibashish Kityania2, Deepa Nath3

  • 1Department of Biotechnology and Microbiology, Techno India University, Tripura, Agartala, India.

The AAPS Journal
|May 13, 2026
PubMed

Insights

Natural compounds show promise in cancer prevention by targeting key pathways. Nanotechnology enhances their delivery and effectiveness, overcoming bioavailability issues for improved cancer treatment strategies.

Area of Science:

  • Oncology and Nanomedicine
  • Natural Product Chemistry
  • Molecular Biology

Background:

  • Cancer is a significant global health concern.
  • Natural compounds like curcumin and resveratrol exhibit anticancer properties by influencing critical signaling pathways (PI3K/Akt, NF-κB, p53).
  • These natural agents can induce apoptosis, autophagy, and DNA repair mechanisms.

Purpose of the Study:

  • To review the synergistic potential of nanotechnology and natural compounds in cancer chemoprevention.
  • To explore how nanotechnology can overcome the limitations of natural compounds in clinical applications.
  • To identify future research directions and translational challenges.

Main Methods:

  • Review of preclinical and clinical studies on nanocarrier-based delivery of natural compounds for cancer.
  • Analysis of various nanocarrier systems including liposomes, polymeric nanoparticles, dendrimers, and albumin-bound nanoparticles.
  • Examination of the impact on pharmacokinetic properties, stability, and targeted delivery.

Main Results:

  • Nanotechnology significantly improves the solubility, stability, and bioavailability of natural anticancer compounds.
  • Nanoparticle formulations enhance the chemopreventive efficacy of natural agents through improved pharmacokinetics and targeted delivery.
  • Preclinical data show enhanced anticancer effects, while early clinical trials indicate both potential and challenges.

Conclusions:

  • The combination of nanotechnology and natural compounds offers a promising strategy for cancer chemoprevention.
  • Overcoming challenges such as immune clearance, scalability, and regulatory hurdles is crucial for clinical translation.
  • Further research is needed to fully realize the therapeutic potential of these synergistic approaches.
Keywords:
cancer chemopreventioncurcumin and resveratrolnanomaterialsnanotechnologytargeted delivery

More Related Videos

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo08:19

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...