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Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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Updated: May 15, 2026

Assessing Microglial Phagocytosis of Myelin Debris in vitro Under Repeated Magnetic Stimulation
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Published on: June 17, 2025

Sustaining microglial reparative function enhances stroke recovery.

Jun Tsuyama1,2,3, Seiichiro Sakai4,5,6, Kumiko Kurabayashi4,5,6

  • 1Department of Neuroinflammation and Repair, Medical Research Laboratory, Institute of Science Tokyo, Tokyo, Japan. tsuyama.j.662a@m.isct.ac.jp.

Nature
|May 13, 2026
PubMed
Summary
This summary is machine-generated.

Researchers found that ZFP384 causes microglia to lose their beneficial functions after a stroke. Targeting ZFP384 can restore these functions and improve brain recovery, even long after the injury.

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Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke
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Published on: October 1, 2020

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Last Updated: May 15, 2026

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Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke
09:41

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke

Published on: October 1, 2020

Area of Science:

  • Neuroscience
  • Immunology
  • Genetics

Background:

  • Neurological deficits after brain injury often persist due to diminished spontaneous recovery.
  • Microglia play a critical role in brain repair, but the mechanisms limiting recovery are not fully understood.

Purpose of the Study:

  • To investigate the cellular and molecular mechanisms behind the loss of microglial reparative functions post-stroke.
  • To identify therapeutic targets for enhancing long-term brain functional recovery.

Main Methods:

  • Cellular fate analysis was employed to track microglial function after stroke.
  • Investigated the role of the transcriptional regulator ZFP384 in microglial dysfunction.
  • Utilized antisense oligonucleotides targeting Zfp384 in preclinical models.

Main Results:

  • Reparative microglia persist post-stroke but lose beneficial functions.
  • ZFP384 was identified as a key regulator diminishing reparative gene expression in microglia.
  • ZFP384 inhibits YY1-mediated chromatin interactions essential for repair gene induction.
  • Targeting Zfp384 with antisense oligonucleotides sustained microglial repair functions and improved chronic stroke recovery.

Conclusions:

  • ZFP384-mediated microglial dysfunction contributes to limited functional recovery after stroke.
  • Therapeutic strategies targeting ZFP384 can restore microglial reparative immunity and promote prolonged brain repair.
  • Preventing the loss of immune cell restorative functions offers a promising approach for enhancing neurological recovery.