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Updated: May 15, 2026

Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke

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Study protocol for the Breathe Easy All Together e-cigarette prevention program: a RE-AIM framework-based

Catriona Lockett^1,2, Smita Shah^3,4, Kym Rizzo Liu¹

¹Prevention Education and Research Unit, Research and Education Network, Western Sydney Local Health District, Sydney, NSW, Australia.

BMC Public Health

|May 14, 2026

Summary

This summary is machine-generated.

The Breathe Easy All Together (BEAT) study evaluates a peer-led intervention to prevent adolescent e-cigarette use in Australian schools. This approach aims to reduce vaping and nicotine addiction among young people.

Keywords:

Adolescence E-cigarettes Peer-Education/Peer-led Prevention School-based intervention Tobacco Vaping

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Area of Science:

Public Health
Adolescent Health
Tobacco Control

Background:

Rising rates of youth e-cigarette use necessitate effective prevention strategies.
The Australian government's tobacco control measures require complementary interventions.
School-based peer leadership programs show promise in influencing social norms around substance use.

Purpose of the Study:

To evaluate the Breathe Easy All Together (BEAT) study, a novel peer-led intervention.
To prevent adolescent e-cigarette use in the Australian school setting.
To assess the process and impact of the intervention using the RE-AIM framework.

Main Methods:

A pre-post test design evaluating the BEAT program using the RE-AIM framework.
Year 10 students trained as peer leaders to deliver health education lessons on e-cigarette resistance to Year 7 students.
Online surveys for students and interviews for staff to assess outcomes and implementation.

Main Results:

The study protocol outlines the evaluation of past-30-day e-cigarette use as the primary outcome.
Secondary outcomes include changes in tobacco use, e-cigarette knowledge, perceptions, refusal skills, and intentions.
Qualitative data from staff interviews will explore intervention acceptability and implementation factors.

Conclusions:

The BEAT study offers a novel peer-led strategy to combat adolescent e-cigarette use in Australia.
This intervention has the potential to safeguard student health from e-cigarette harms and nicotine addiction.
The RE-AIM framework provides a robust method for evaluating school-based interventions, with potential for wider dissemination if effective.