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A Method for Quantifying Upper Limb Performance in Daily Life Using Accelerometers
Published on: April 21, 2017
Accelerometer-derived "weekend warrior" physical activity pattern and trajectory of cardio-renal-metabolic
Zhouyang Sun1, Tingyi Jia1, Meng Li1
1Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, 1163 Xinmin Street, Changchun, Jilin, 130021, China.
Insights
Regular physical activity, including weekend warrior patterns, significantly lowers the risk of developing cardio-renal-metabolic diseases and their progression. This highlights the public health importance of moderate-to-vigorous physical activity for early disease prevention.
Area of Science:
- Public Health
- Epidemiology
- Preventive Medicine
Background:
- Cardio-renal-metabolic multimorbidity (CRMM) is a significant public health issue.
- Moderate-to-vigorous physical activity (MVPA) may prevent individual CRMM components.
- Longitudinal studies on MVPA and CRMM progression are limited.
Purpose of the Study:
- To investigate the association between MVPA patterns and the risk of CRMM onset and progression.
- To analyze transitions between healthy state, first CRMM, CRMM, and mortality.
- To assess the impact of different physical activity levels on disease trajectories.
Main Methods:
- Analysis of 76,875 UK Biobank participants using accelerometer data.
- Categorization of MVPA into inactive, regularly active, and weekend warrior (WW) patterns.
- Application of multi-state models to analyze longitudinal disease transitions and mortality.
Main Results:
- Regularly active and WW patterns were associated with reduced risk of transitioning from healthy to first CRMM.
- Both activity patterns also lowered the risk of progression from first CRMM to CRMM.
- Protective effects were more pronounced in women for initial CRMM development and in non-hypertensive individuals for disease progression.
Conclusions:
- Both regularly active and weekend warrior MVPA patterns are linked to lower risks of CRMM onset and progression.
- These findings emphasize the public health significance of MVPA for early disease prevention.
- Early intervention strategies focusing on MVPA are crucial for precision prevention of CRMM.
Background:
Cardio-renal-metabolic multimorbidity (CRMM), defined as the coexistence of at least two of cardiovascular disease (CVD), type 2 diabetes (T2D), and chronic kidney disease (CKD), poses a major public health challenge. Moderate-to-vigorous physical activity (MVPA) may reduce the risk of these individual diseases, yet studies examining its association with longitudinal disease progression are lacking.
Methods:
We analyzed 76,875 UK Biobank participants with valid 7-day wrist-worn accelerometer data (2013-2015). MVPA patterns were categorized as inactive, regularly active, or weekend warrior (WW). Multi-state models were used to characterize longitudinal transitions from a healthy state to first cardio-renal-metabolic disease (FCRMD), subsequent progression to CRMM, and all-cause mortality. Fully adjusted Cox and multi-state models estimated effect sizes, with subgroup and sensitivity analyses assessing robustness.
Results:
Over a median follow-up of 8.1 years, 8,495 participants developed FCRMD, 934 progressed to CRMM, and 2,373 died. Compared with inactive participants, regularly active (HR = 0.82, 95% CI: 0.77-0.87) and WW (HR = 0.83, 95% CI: 0.79-0.87) had lower risks of transitioning from healthy to FCRMD and from FCRMD to CRMM (regularly active: HR = 0.75, 95% CI: 0.62-0.91; WW: HR = 0.81, 95% CI: 0.69-0.94), with reduced mortality across other transitions except CRMM-to-death. Protective effects were stronger among women for the transition to FCRMD and among participants without hypertension during subsequent disease progression. Subgroup and sensitivity analyses confirmed robustness.
Conclusions:
Both regularly active and weekend warrior patterns of baseline MVPA were associated with lower risks of CRMD onset and progression, particularly during the early stages, underscoring the public health value of MVPA and the importance of early intervention for precision prevention.
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