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Related Concept Videos

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Related Experiment Video

Updated: May 15, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Vesicle-Templated Self-Assembly of Programmable Freestanding Multi-μm DNA Shells.

Hao Yuan Yang1,2, Christoph Karfusehr1,2, Friedrich C Simmel1,2

  • 1Department of Bioscience, TUM School of Natural Sciences, Technical University of Munich, Am Coulombwall 4a, 85748 Garching, Germany.

Nano Letters
|May 14, 2026
PubMed
Summary
This summary is machine-generated.

Researchers created freestanding DNA shells that mimic cell membranes. This novel compartmentalization method uses DNA nanostructures and offers new possibilities for bottom-up synthetic biology.

Keywords:
DNA nanotechnologycompartmentalizationself-assemblysynthetic biology

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Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
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Last Updated: May 15, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

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Published on: May 8, 2015

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
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Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

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Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

Area of Science:

  • Synthetic Biology
  • Nanotechnology
  • Biochemistry

Background:

  • DNA nanostructures are used to functionalize or scaffold lipid vesicles for synthetic cell applications.
  • Existing methods often involve direct integration with lipid bilayers.

Purpose of the Study:

  • To develop a broadly applicable method for creating freestanding, membrane-mimicking DNA shells.
  • To demonstrate the versatility of DNA architectures for shell formation.
  • To explore new compartmentalization strategies for synthetic biology.

Main Methods:

  • DNA shells assembled on giant unilamellar vesicles (GUVs).
  • Surfactant-mediated removal of liposomes to liberate freestanding DNA shells.
  • Utilized DNA origami and nanostar-inspired DNA motifs as building blocks.

Main Results:

  • Successfully generated freestanding DNA shells templated by GUVs.
  • Demonstrated shell formation using both complex DNA origami and simpler DNA motifs.
  • Showcased controlled multilayer shell formation via DNA origami's addressability.

Conclusions:

  • The method provides a versatile approach to DNA-only shell compartments.
  • These DNA shells mimic cell membrane geometry and size range.
  • Offers a novel compartmentalization strategy for bottom-up synthetic biology.