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Published on: January 14, 2014

Associations of High-Sensitivity Cardiac Troponin and N-Terminal Pro-B-Type Natriuretic Peptide With

Mingdan Wang1, Xihan Li1, Lingyue Qiu1

  • 1Center For Clinical and Epidemiologic Research, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, National Clinical Research Center For Cardiovascular Diseases, Beijing, China.

Journal of Clinical Hypertension (Greenwich, Conn.)
|May 14, 2026
PubMed

Insights

Elevated high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) indicate subclinical cardiac changes in hypertensive patients. These biomarkers are linked to left ventricular remodeling, impaired function, and arterial enlargement.

Area of Science:

  • Cardiology
  • Biomarkers
  • Hypertension Research

Background:

  • High-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are established markers for cardiac dysfunction.
  • Limited data exist on their association with multidimensional echocardiographic features in hypertensive individuals.

Purpose of the Study:

  • To investigate the relationship between hs-cTnT and NT-proBNP levels and echocardiographic parameters in patients with hypertension.
  • To assess the combined impact of these biomarkers on cardiac structure and function.

Main Methods:

  • A multicenter prospective cohort study included 1803 hypertensive adults who underwent echocardiography.
  • Serum hs-cTnT and NT-proBNP levels were measured and analyzed in association with echocardiographic features using multivariable-adjusted models.

Main Results:

  • Higher hs-cTnT levels correlated with increased left ventricular and atrial remodeling, and higher flow velocity.
  • Elevated NT-proBNP was associated with structural changes, impaired diastolic function, and arterial enlargement.
  • The highest tertiles for both biomarkers showed the most pronounced cardiac abnormalities, including increased interventricular septum thickness and worse diastolic function.

Conclusions:

  • Elevations in hs-cTnT and/or NT-proBNP are associated with subclinical cardiac structural and functional abnormalities in hypertensive patients.
  • These biomarkers may help identify individuals at risk for cardiac complications within the hypertensive population.

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