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Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...

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Related Experiment Video

Updated: May 15, 2026

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

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Published on: May 17, 2019

Hsa-miR-23a-5p: A Potential Prognostic Biomarker in Diffuse Large B-cell Lymphoma.

Yunfei Zhao1, Anna Su2, Rui Bai3

  • 1Department of Oncology, The Fourth Clinical Medical College of Xinjiang Medical University, Urumqi, China. zhao30703117@163.com.

Iranian Journal of Allergy, Asthma, and Immunology
|May 14, 2026
PubMed
Summary
This summary is machine-generated.

Researchers identified hsa-miR-23a-5p as a novel biomarker for diffuse large B-cell lymphoma (DLBCL). Overexpressed in DLBCL tissues and serum exosomes, it correlates with prognosis and chemoresistance, offering a potential non-invasive diagnostic tool.

Keywords:
Diffuse large B‐cell lymphomaExosomeMicroRNAPrognosis

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Area of Science:

  • Molecular Oncology
  • Biomarker Discovery
  • MicroRNA Research

Background:

  • Diffuse large B-cell lymphoma (DLBCL) requires accessible biomarkers for dynamic monitoring.
  • MicroRNAs (miRNAs) are implicated in cancer pathogenesis and progression.
  • Circulating miRNAs offer potential for non-invasive diagnostics.

Purpose of the Study:

  • To identify a novel, clinically accessible miRNA biomarker for DLBCL.
  • To investigate the role of hsa-miR-23a-5p in DLBCL prognosis and immune microenvironment.
  • To explore hsa-miR-23a-5p as a potential non-invasive biomarker for DLBCL monitoring.

Main Methods:

  • Analysis of miRNA expression profiles from GEO and TCGA databases.
  • Assessment of immune microenvironment using CIBERSORT and gene set enrichment analysis.
  • Identification and validation of miRNA targets (SNRPD1) using bioinformatics tools and databases.

Main Results:

  • Hsa-miR-23a-5p was significantly overexpressed in DLBCL tumor tissues and serum exosomes.
  • Hsa-miR-23a-5p expression correlated with distinct prognostic outcomes, immune landscapes, and chemoresistance.
  • The target gene SNRPD1 was identified as an independent prognostic factor for patient survival.

Conclusions:

  • Hsa-miR-23a-5p and its target SNRPD1 are potential prognostic factors for DLBCL.
  • Overexpressed hsa-miR-23a-5p in serum exosomes suggests its utility as a non-invasive DLBCL biomarker.
  • Further validation is required to confirm the clinical applicability of hsa-miR-23a-5p in DLBCL management.