Related Experiment Video

Updated: May 15, 2026

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes
03:19

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes

Published on: June 28, 2024

[Occurrence status and treatment strategies of abnormal growth and development in children with methylmalonic

Hai-Yan Wei1, Dong-Xiao Li1

  • 1Department of Endocrinology and Metabolism, Henan Provincial Children's Hospital/Affiliated Children's Hospital of Zhengzhou University, Zhengzhou 450052, China.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|May 14, 2026
PubMed

Insights

Methylmalonic acidemia (MMA) significantly impacts child growth and development, leading to neurodevelopmental delays and poor outcomes. This review explores MMA

Area of Science:

  • Biochemistry
  • Pediatric Endocrinology
  • Metabolic Disorders

Background:

  • Methylmalonic acidemia (MMA) is a common organic acid metabolism disorder.
  • Growth and developmental abnormalities are significant challenges in MMA, impacting prognosis.
  • Neurodevelopmental delay and impaired somatic growth are key determinants of poor long-term outcomes.

Purpose of the Study:

  • To review the occurrence, mechanisms, and interventions for growth and developmental abnormalities in MMA.
  • To provide a reference for optimizing clinical management and improving patient outcomes.

Main Methods:

  • Literature review focusing on methylmalonic acidemia.
  • Analysis of studies on growth and developmental outcomes in pediatric patients.
  • Synthesis of information on etiological factors and therapeutic strategies.

Main Results:

  • Growth and developmental issues are prominent in MMA patients.
  • Heterogeneous clinical manifestations complicate assessment and management.
  • Early identification and individualized interventions are crucial.

Conclusions:

  • Addressing growth and developmental abnormalities is central to MMA management.
  • Optimized patient management requires a focus on early identification, assessment, and intervention.
  • Improving long-term outcomes in MMA necessitates a comprehensive approach to developmental challenges.

Keywords:
ChildDevelopmental abnormalityGrowth hormoneMethylmalonic acidemiaPathogenesis

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