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Pulvinar subdivisions and connectivity patterns across primate species: a comparative perspective.
Juliana G M Soares1, Amaro R A Correia1,2, Ricardo Gattass1
1Laboratory of Cognitive Physiology, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Frontiers in Neuroanatomy
|May 14, 2026
Summary
This review synthesizes non-human primate and human studies on thalamic pulvinar nucleus connectivity. Understanding these connections is crucial for developing targeted brain stimulation therapies for neurological conditions like epilepsy.
Area of Science:
- Neuroscience
- Neuromodulation
- Brain Stimulation
Background:
- Advances in brain stimulation techniques like transcranial magnetic stimulation (TMS) and deep brain stimulation (DBS) are vital for neuroscience research and treating neurological disorders.
- Neuromodulatory interventions show promise for epilepsy treatment, highlighting the thalamic pulvinar nucleus as a key target for drug-resistant cases.
Purpose of the Study:
- To review cortico-pulvinar connectivity patterns of distinct pulvinar subregions.
- To integrate findings from non-human primate (NHP) studies with available human studies.
- To provide a foundation for optimizing future brain stimulation therapies targeting the pulvinar nucleus.
Main Methods:
- Literature review of non-human primate (NHP) studies on pulvinar connectivity.
- Inclusion of available human neuroimaging studies (e.g., diffusion imaging, fMRI).
Main Results:
- Detailed review of cortico-pulvinar connections across different pulvinar subregions in NHPs.
- Synthesis of existing human data on pulvinar connectivity patterns.
Conclusions:
- A comprehensive understanding of pulvinar subdivisions and connectivity is essential for advancing brain stimulation therapies.
- This review facilitates the optimization of targeted neuromodulation strategies for neurological conditions, particularly epilepsy.
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