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The Role of Extracellular Vesicles MicroRNAs in Sarcopenia: From Aging to Multi-Morbidity
Bingyu Huang1, Zhao Peng1, Lin Kang2
1Department of Internal Medicine, Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China.
None:
Sarcopenia, defined as progressive loss of skeletal muscle mass and function, occurs during aging and has also been recognized for its detrimental effects in various disease states. Its prevention and management represent a critical aspect of geriatric care and multi-morbidity management. As a systemic disorder, extracellular vesicle-transported miRNAs mediate both intrinsic muscle pathology and multifaceted organ crosstalk. This review comprehensively summarizes and discusses the roles of EVs-miRNAs in sarcopenia under physiological aging and pathological conditions, and their emerging potential as diagnostic biomarkers and engineered therapeutic targets.
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