PTM encoding: decoding the mechanisms of exercise-induced metabolic memory through spatiotemporal modification...

Area of Science:

• Biochemistry and Molecular Biology
• Physiology
• Metabolic Regulation

Background:

• Post-translational modifications (PTMs) are crucial for cellular responses to stimuli like exercise.
• Understanding PTM coordination is key to decoding metabolic memory, particularly in skeletal muscle glucose uptake.
• Existing research often overlooks the complex network dynamics of PTMs in metabolic adaptations.

Purpose of the Study:

• To review recent advances in PTM-mediated regulation of exercise-induced metabolic memory.
• To highlight the integration of cutting-edge technologies for dynamic PTM profiling.
• To explore the molecular logic and translational applications of PTM research.

Main Methods:

• Synthesis of recent scientific literature on PTMs and metabolic memory.
• Emphasis on advanced technologies: single-cell multiomics and in situ mass spectrometry imaging.
• Discussion of innovations in fluorescence reporter probes for in vivo PTM monitoring.

Main Results:

• PTMs play a central role in exercise-induced metabolic memory.
• Hierarchical PTM networks and interorgan communication, regulated by AMPK/mTOR pathways, are critical.
• Machine learning models offer quantitative frameworks for tracking metabolic states.

Conclusions:

• Integrating advanced technologies provides high-resolution PTM dynamics.
• PTM-mediated regulation is a transformative paradigm for understanding metabolic memory.
• This research advances personalized exercise prescriptions and clinical interventions.