Related Experiment Video
Updated: May 15, 2026
12:18
Assessing Biofilm Dispersal in Murine Wounds
Published on: August 7, 2021
A pilot study on microbial dynamics in drainage fluid during trauma recovery
Hyun-Hee Hong1,2, Tae-Hwan Kim3, Dowan Kim4
1School of Biological Sciences and Technology, Chonnam National University, Gwangju, Korea.
Annals of Surgical Treatment and Research
|May 14, 2026
Summary
Drainage fluid microbiome analysis reveals distinct microbial communities and shifts during trauma recovery. These findings suggest potential for microbiome-based monitoring in trauma surgery patients.
Area of Science:
- Microbiology
- Trauma Surgery
- Immunology
Background:
- Drainage fluid offers insights into immune and infectious status post-trauma surgery.
- Microbiome shifts in drainage fluid during recovery are not well understood.
Purpose of the Study:
- Investigate microbial dynamics in drainage fluid during intensive care unit (ICU) and ward recovery phases.
- Characterize microbiome shifts associated with clinical resilience in Korean trauma patients.
Main Methods:
- Collected drainage and stool samples from 10 trauma patients.
- Analyzed microbial composition using 16S ribosomal RNA amplicon sequencing.
- Compared microbial diversity and identified recovery-associated taxa and metabolic pathways.
Main Results:
- Drainage fluid harbored distinct microbial communities, with increased shared taxa in patients with bowel injury indicating translocation.
- Seven genera and 5 species decreased during ward recovery, with *Modestobacter* and *Blastococcus tunisiensis* showing high discriminative ability.
- Predicted metabolic pathways related to degradation and inflammation were more active during the ICU stage.
Conclusions:
- Drainage fluid microbiome profiles may reflect trauma recovery dynamics.
- Supports potential utility for microbiome-based monitoring and biomarker discovery in trauma surgery.
