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Related Experiment Video

Updated: May 15, 2026

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
09:09

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection

Published on: March 14, 2019

Using C-Reactive Protein Measurements to Predict Treatment Failure in Native Vertebral Osteomyelitis: A Multisite

Brendan Campbell1, Tim Lahey1, Andrew J Hale1

  • 1Division of Infectious Diseases, Department of Medicine, University of Vermont Medical Center, Burlington, Vermont, USA.

Open Forum Infectious Diseases
|May 14, 2026
PubMed
Summary

Serial C-reactive protein (CRP) measurements show a weak association with treatment failure in native vertebral osteomyelitis (NVO). This common practice for monitoring NVO treatment response is likely of little clinical value.

Keywords:
C-reactive proteinantimicrobial managementepidural abscessoutpatient parenteral antibiotic therapyvertebral osteomyelitis

Related Experiment Videos

Last Updated: May 15, 2026

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
09:09

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection

Published on: March 14, 2019

Area of Science:

  • Infectious Diseases
  • Orthopedic Surgery
  • Clinical Pathology

Background:

  • Native vertebral osteomyelitis (NVO) management is challenging due to limited prognostic tools.
  • Serial serum C-reactive protein (CRP) is commonly used to assess treatment response in NVO.
  • Evidence supporting CRP's utility in predicting NVO treatment outcomes is limited.

Purpose of the Study:

  • To evaluate the predictive value of C-reactive protein (CRP) assessment for treatment failure in native vertebral osteomyelitis (NVO).

Main Methods:

  • A multisite retrospective cohort study was conducted.
  • Included adults with NVO treated with antibiotics for ≥6 weeks and at least two CRP values.
  • Primary outcome was microbiologic or clinical failure within 6 months of diagnosis.

Main Results:

  • Univariate analysis showed significant differences in last CRP values and percent decrease between treatment success and failure groups.
  • Multivariate analysis, adjusting for Staphylococcus aureus infection and epidural abscess, revealed weak and nonsignificant associations between CRP values and treatment failure.
  • Odds ratios for median last CRP value and percent difference were 1.02 (P=.06) and 0.99 (P=.11), respectively.

Conclusions:

  • Serial CRP measurements demonstrate only a weak association with treatment failure in NVO.
  • The common clinical practice of using serial CRP to guide NVO treatment decisions appears to have limited value.