Intravenous Administration of Hyaluronan in Veterinary Musculoskeletal Disorders: Therapeutic Applications and...

Hyaluronan (HA), a natural polysaccharide, is a significant component in the extracellular matrix of connective tissues. Recently, HA has gained substantial attention in veterinary medicine due to its remarkable effects in promoting wound healing and supporting joint health. The route of administration plays a key role in the therapeutic potential of HA, as it affects the pharmacokinetics and bioavailability of HA within the body and diseased joints. Moreover, administration routes differ considerably regarding technical complexity and patient discomfort. This review summarizes recent studies exploring therapeutic applications of intravenous HA across various medical conditions, animal species, and clinical settings, emphasizing specific therapeutic effects, underlying mechanisms, clinical efficacy, and overall therapeutic potential, highlighting systemic effects beneficial for multijoint and systemic connective tissue conditions.