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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: May 15, 2026

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
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Published on: September 13, 2022

Decoding WDR5-Mediated Interactions in Gliomas: Implications for Targeted Therapy.

Edmund Jung1, Christina Piperi1

  • 1Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Medicinal Research Reviews
|May 14, 2026
PubMed
Summary

WD repeat domain 5 (WDR5) is crucial for glioma growth and resistance by regulating gene expression. Targeting WDR5 with inhibitors or degraders shows promise for suppressing tumor progression and offers new therapeutic strategies.

Keywords:
H3K4me3HBI‐2375MLLMYCWDR5WRADgliomas

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Last Updated: May 15, 2026

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
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Published on: September 13, 2022

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Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis

Published on: March 20, 2026

Area of Science:

  • Neuro-oncology
  • Cancer Epigenetics
  • Molecular Biology

Background:

  • Gliomas are aggressive brain tumors with poor prognosis, driven by genetic and epigenetic alterations.
  • Epigenetic regulators, like WD repeat domain 5 (WDR5), are increasingly recognized for their role in glioma growth and treatment resistance.
  • WDR5 is a key component of the WRAD complex, essential for H3K4 trimethylation (H3K4me3) and associated oncogenic transcriptional programs.

Purpose of the Study:

  • To review the significant role of WDR5 in gliomas.
  • To highlight WDR5 as a tumor-specific epigenetic vulnerability.
  • To provide an update on WDR5-targeted inhibitors and degraders for glioma therapy.

Main Methods:

  • Literature review focusing on WDR5's function in gliomas.
  • Analysis of WDR5's role in epigenetic regulation, including H3K4me3.
  • Evaluation of WDR5-targeted therapeutic strategies (inhibitors, PROTAC degraders).

Main Results:

  • WDR5 expression is elevated in gliomas, promoting proliferation, migration, and stemness.
  • WDR5 supports MYC-driven oncogenic activity through H3K4me3-mediated gene regulation.
  • Targeting WDR5 impairs WRAD complex assembly, reduces H3K4me3, and suppresses glioma growth.

Conclusions:

  • WDR5 is a critical epigenetic vulnerability in gliomas.
  • WDR5 inhibitors and degraders demonstrate therapeutic potential for glioma treatment.
  • Targeting WDR5 offers a promising avenue for future glioma therapies.