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Related Experiment Video

Updated: May 15, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

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Published on: April 23, 2021

Prior Myocardial Infarction and Cognitive Decline: The REGARDS Cohort.

Mohamed Ridha¹, Musarrat Nahid², Emily B Levitan³

¹Department of Neurology, The Ohio State University, Columbus (M.R.).

|May 14, 2026

Summary

This summary is machine-generated.

Prior myocardial infarction (MI), detected via ECG or history, is linked to faster cognitive decline. This finding suggests MI may help identify individuals at risk for future cognitive impairment.

Keywords:

cardiovascular diseases cognition cohort studies myocardial infarction risk factors

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Area of Science:

Cardiology
Neurology
Public Health

Background:

Acute myocardial infarction (MI) is a known risk factor for cognitive decline.
The utility of routine electrocardiogram (ECG) and patient history in identifying different cognitive decline trajectories post-MI remains unclear.
A national, biracial cohort study investigated the association between prior MI and longitudinal cognitive function.

Purpose of the Study:

To determine if prior MI, detected by ECG and self-report, is associated with distinct longitudinal cognitive decline patterns.
To analyze cognitive trajectories in individuals with self-reported, clinical, and silent MI.
To assess the predictive value of prior MI for future cognitive impairment.

Main Methods:

The Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort (2003-2007) included participants with interpretable ECGs and no baseline cognitive impairment.
Prior MI was categorized as self-reported, clinical (Q-wave MI with history), or silent (Q-wave MI without history).
Linear mixed-effects models analyzed global cognitive function (6-item screener) over a median of 10.1 years, adjusting for covariates and censoring for death.

Main Results:

The cohort comprised 20,923 individuals, with 2,183 showing prior MI (1098 self-reported, 281 clinical, 804 silent).
Prior MI was significantly associated with accelerated annual global cognitive decline (adjusted annual decline: -0.016 points).
All MI types (self-reported, clinical, silent) demonstrated similar accelerated cognitive decline trajectories.

Conclusions:

Prior MI, encompassing clinically recognized and silent forms, is associated with accelerated global cognitive decline.
Identifying individuals with prior MI, regardless of clinical recognition, may help pinpoint those at higher risk for cognitive impairment.
This study highlights the importance of considering MI history in assessing long-term cognitive health.