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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation: Introduction01:28

Inflammation: Introduction

Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
Inflammation01:38

Inflammation

Overview
Allergic Reactions02:06

Allergic Reactions

Overview

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Related Experiment Video

Updated: May 15, 2026

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
07:48

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation

Published on: May 16, 2016

STING: An Attractive Target for Autoimmune and Inflammatory Diseases.

Zhenjiao Yang1, Xinqiao Liu1, Jinhong Zhan1

  • 1Balance-Based Drug Discovery Laboratory, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.

Medicinal Research Reviews
|May 14, 2026
PubMed
Summary

Stimulator of Interferon Genes (STING) protein hyperactivation drives autoimmune diseases. This review summarizes STING inhibitors and degraders, highlighting design strategies and future drug discovery opportunities for these challenging therapeutics.

Keywords:
PROTACSTINGautoimmuneinflammatory diseasessmall‐molecule inhibitors

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Area of Science:

  • Immunology
  • Drug Discovery
  • Molecular Biology

Background:

  • Stimulator of Interferon Genes (STING) is crucial for innate immunity.
  • STING hyperactivation is implicated in autoimmune and inflammatory diseases.
  • STING is a promising therapeutic target for these conditions.

Purpose of the Study:

  • To comprehensively review recent advances in STING inhibitors and degraders.
  • To highlight design strategies for STING-targeting drugs.
  • To discuss challenges and opportunities in STING drug discovery.

Main Methods:

  • Literature review of STING inhibitor and degrader development.
  • Analysis of design strategies and therapeutic potential.
  • Discussion of current challenges and future directions.

Main Results:

  • Numerous STING inhibitors and degraders have been developed.
  • Various design strategies are employed to target STING.
  • Drug candidate development for STING remains challenging and nascent.

Conclusions:

  • STING inhibition presents a promising therapeutic avenue for autoimmune diseases.
  • Further research is needed to overcome challenges in STING drug development.
  • This perspective aims to guide future STING drug discovery efforts.