STING: An Attractive Target for Autoimmune and Inflammatory Diseases

Stimulator of Interferon Genes (STING) is a transmembrane homodimer protein located in the endoplasmic reticulum membrane and plays an essential role in human innate immunity. Hyperactivation of STING has been found in many autoimmune and inflammatory diseases. Therefore, STING has been recognized as a promising target for the treatment of these diseases. Many efforts have been devoted to identifying STING inhibitors and degraders. However, development of STING drug candidates is still challenging and in its infancy, and no candidates have been advanced into clinical trials. In this perspective, we comprehensively summarize recent advances in the development of STING inhibitors and degraders and highlight their design strategies. We also discuss the challenges and opportunities of STING inhibition and expect to shed light on future STING drug discovery.