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Arrow promotes nociceptive sensitivity in Drosophila melanogaster

Trevor Flanagan1, Michael Caterina1, Tatiana Muteba2

  • 1University of New England College of Arts and Sciences, Biddeford, ME, USA.

Molecular Pain
|May 14, 2026
PubMed
Abstract

Keywords:
LRP5/6Nociceptorpainwgwinglesswnt

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Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...