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PERIVASCULAR MULTIFOCAL CHOROIDITIS WITH PANUVEITIS: Clinical and Multimodal Imaging Features.
Alessandro Feo1,2, Alberto Quarta3, Demi A Miller1
1Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Retina (Philadelphia, Pa.)
|May 14, 2026
Summary
The perivascular phenotype of multifocal choroiditis with panuveitis (PV-MFCPU) shows distinct long-term clinical and imaging features. Early recognition of PV-MFCPU aids in differentiating it from other inflammatory eye conditions.
Area of Science:
- Ophthalmology
- Medical Imaging
- Retinal Diseases
Background:
- Multifocal choroiditis with panuveitis (MFCPU) is an inflammatory eye condition.
- A specific perivascular distribution of lesions has been observed in some MFCPU cases.
Purpose of the Study:
- To characterize the long-term clinical and imaging findings of the perivascular phenotype of multifocal choroiditis with panuveitis (PV-MFCPU).
Main Methods:
- Retrospective observational case series of eight patients with PV-MFCPU.
- Multimodal imaging including CFP, FAF, FA, OCT, and OCT angiography was analyzed.
- Comprehensive systemic work-up excluded other potential etiologies.
Main Results:
- PV-MFCPU lesions showed a perivascular distribution, often in the periphery.
- Imaging revealed hypoautofluorescent spots evolving into atrophic scars, with RPE and outer retinal disruption on OCT.
- Best-corrected visual acuity remained stable, with some cases developing choroidal neovascularization responsive to anti-VEGF therapy.
Conclusions:
- PV-MFCPU is a distinct topographic phenotype within the MFCPU spectrum.
- Identifying PV-MFCPU aids in distinguishing it from vasculitic and inflammatory chorioretinal mimics.
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