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Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
Published on: September 24, 2020
The ICU environment paradigm as a catalyst for better delirium models
1Department of Anesthesiology, Division of Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut, U.S.A.
None:
The present commentary argues that incorporating ICU-like environmental stressors into animal delirium models improves translational validity. By combining surgery or sepsis with light, noise, sleep disruption, and handling, the discussed paradigm better reflects human ICU delirium, supports mechanistic discovery, and highlights circadian disruption as a promising framework for future investigation.
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